When it comes to some illnesses, you don’t directly treat the parasite: you manage the symptoms. In the case of kratom, the alkaloid properties do just that. While modern scientific advancements are only beginning to uncover the anti-malarial benefits of kratom, many tribal communities in malaria-stricken regions have used such a plant for centuries.

  • First, it is essential to break down what components kratom releases when applied to a case of malarial infection.

Ultimately, the relevant properties are as follows:

Mitragynine (66%)

  • This chemical has pain relieving properties which soothe the aches, and other pains brought forth from malaria. This chemical also acts as a cough suppressant.
  • One of the most dangerous aspects of malaria is diarrhea. Diarrhea itself is not the issue; the body is more than capable of expelling feces at rapid rates.
  • The critical portion is the dehydration that follows. This chemical serves to retain much-needed water within the body.
  • Another critical factor is that malaria may express itself in many different forms, such as cerebral malaria. This chemical serves to stimulate the nervous system in a way that impedes nervous cell damage from such an infection.

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Paynantheine (9%) and Speciogynine (7%)

  • Malaria targets the skeleton muscles in the body. Causing fatigue in an already depleted body, aches, contractures, and overall pain. These two chemicals suppress this as they target the smooth muscles in the body

7-hydroxymitragynine(2%)

  • This chemical serves many similar purposes for the body, as does Mitragynine.
  • It relieves the aches induced by malaria, suppresses coughing, and functions vital role of suppressing the symptom of diarrhea, thus retaining much-needed water within the body
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Speciogynine (1%)

  • Though not potent in its effects on the body, it does serve as an opioid antagonist. Much like how morphine, when used responsibly, can both sedate the inflicted while reducing aches and pains brought on from the infection.

Mitraphylline (<1%) 

  • One of the more insidious aspects of malaria is that affected cells stiffen, which causes blockages within blood vessels, as well as arterial stiffness.
  • This chemical is responsible for expanding the blood vessels, thus allowing great passage of blood to vital organs, and reducing blood vessel blockage.

Along with effects on the blood, this chemical combats high blood pressure, a symptom of the infection. This chemical, much like muscle Paynantheine and Speciogynine, serves to reduce malarial symptoms relating to skeletal muscles.

  • As a note, this chemical does serve as a mild diuretic; thus increasing the amount of urine being passed through the body.
  • While this works against the need to retain the bodies’ fluids, the reduction of diarrhea is by far a higher priority, as the amount of fluids leaving from urine is far below the amount that would be expelled through feces.

Malaria is also responsible for a host of psychiatric issues, such as memory loss.

  • This chemical helps to suppress this symptom as it relates to the brain’s neural network.
  • Given that the body’s immune system is very much needed in the fight agent malaria, this chemical has been found to stimulate vital parts of the immune system.

Iso Mitraphylline (<1%)

  • This chemical has also been found to stimulate the immune system, much like Mitraphylline.
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Rhynchophylline (<1%)

  • Similar to Mitraphylline, this chemical widens the blood vessels and reduce blood pressure. Unlike the other compounds, this chemical serves as a calcium channel blocker.
  • It has been discovered that inhibiting calcium channels helps to limit the spread of infection. Malarial parasites require calcium both for intracellular growth, and to invade other erythrocytes (much like a virus would).

As we previously covered, malarial infections can cause blood vein blockages.

  • This chemical directly inhibits the sticking together of platelets in the blood. However, this chemical isn’t perfect. It does directly serve to reduce inflammation, something that malarial parasites do themselves, which compromises the immune system as a whole.
  • With that being adequately acknowledged, the benefits of the chemical far outnumber the issues. Another example is the reduction of fever.
  • Common knowledge being the body does its best to maintain an internal temperature of 98.6 degrees Fahrenheit (37 degrees Celsius).
  • This is vital as the body can quickly compromise its own health in increasing the bodies’ temperature in an attempt to combat the malarial parasites.
  • Given that the body is strained both on a muscular level and in matters of the blood, this chemical protects the heart as it serves to reduce irregular heartbeats.

Not many chemicals found in local fauna directly combat the malarial parasites.

However, this chemical does.

It does so by either stunning or killing the parasites themselves, leaving the body to expel them at a later time.

Isorhynchophylline (<1%)

  • Much like Mitraphylline, this chemical directly stimulates vital parts of the immune system.
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Ajmalicine (<1%)

  • As previously covered, malaria can affect the brains’ cerebral cortex. This herb actively stimulates the blood flow to the cortex, thus allowing for faster and greater delivery immune system cells, and flushing out malarial parasites.
  • Like Rhynchophylline, this chemical serves to reduce platelet sticking in blood vessels, as well as combating hypertension in the body.

As many malaria survivors can tell you, the experience can be ridden with anxiety. This chemical actively sedates the infected person.

It relaxes smooth muscles and directly inhibits convulsion, a dangerous and damaging symptom that affects the bodies’ muscles.

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Corynantheidine (<1%)

  • Like Speciogynine, this chemical acts as an opioid receptor antagonist.

Corynoxine A <1%

  • Calcium channel blocker, anti-locomotive

Corynoxine B <1%

  • This chemical helps to reduce the activity of the muscles, thus decreasing damages imposed by convulsions and other muscular infection symptoms.

Ciliaphylline (<1%)

  • Suppresses coughing and pain much like Mitragynine.

Speciofoline (<1%)

  • Suppresses a cough and pain, much like Ciliaphylline, and Mitragynine.
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